Druggability of Pharmaceutical Compounds

Did you every consider that your most potent molecule may not be the one you should develop? That compound with picomolar binding affinity may be far too unstable or insoluble or metabolically labile to ever make it to market.

PharmaDirections designs and manages material-efficient "druggability" studies to assist in lead selection or to elucidate potential roadblocks in developing specific molecules. Parameters that may be considered include:

• Chemical stability
• Metabolic stability
• Solubility
• Permeability/Bioavailability
• Crystallinity
• Powder characteristics
• Cost and complexity of synthesis
• Polymorphism
• In-Vivo testing