GastroPlus™

The formulation and PK experts at PharmaDirections use a variety of software packages that allow them to develop formulations and products that are sure to meet their physiological goals. The use of GastroPlus™ allows them unprecedented approaches to understanding the disposition and delivery of orally or nasally delivered drugs.

PharmaDirections licenses GastoPlus™ from Simulations Plus for use in our drug discovery and formulation development projects
Advanced software program that simulates absorption, pharmacokinetics, and pharmacodynamics in animals and in humans
Whole-body physiological models for human (fasted and fed), beagle dog (fasted and fed), rat (fasted and fed), mouse (fasted and fed), and cyno monkey
Dosage forms: IV, solid oral (immediate and controlled release), liquid, buccal, sublingual pH-dependent solubility and logD models
Mechanistic effect of bile salts on in vivo drug solubility and dissolution
Enhanced treatment of nanoparticle effects on solubility and dissolution
Dissolution and precipitation dependence on particle size, shape and particle density
Chemical degradation of drug in intestinal lumen prior to absorption
Virtual Trials - predict likely population distributions of PK/PD results