Oral Bioavailability
Bioavailability is the determination of the fraction of a drug that reaches the blood stream when compared to the amount of the drug that is administered as a bolus IV. When a drug given orally its bioavailability generally is lower due to a number of factors such as solubility, stability in body fluids, absorption or first-pass metabolism. When we develop oral formulations we use PK modeling and our deep understanding of pharmacokinetics and GI physiology to determine the best way and the best technology to deliver the drug.
We use industry standard tools, such as WinNonLin and GastroPlus™ to go a step further in providing a deep scientific insight into how PK parameters impact the development pathway and the design of optimal dosage forms. Activities we support include:
- Predicting human bioavailability from animal data
- Designing dosage forms for poorly soluble drugs
- Generating Intellectual Property (Learn more)
- Pharmacokinetic modeling to predict oral bioavailability
- Pharmacokinetic modeling to design formulations that improve clinical efficacy or reduce side effects